Showing 3 results for Curcumin
Shadi Moshayedi, Hossein Sarpoolaky, Alireza Khavandi,
Volume 19, Issue 2 (6-2022)
Abstract
In this paper, chemically-crosslinked gelatin/chitosan hydrogels containg zinc oxide nanoparticles (ZNPs), were loaded with curcumin (CUR), and their microstructural features, physical properties, curcumin entrapment efficiency, and drug release kinetics were evaluated using scanning electron microscopy (SEM), the liquid displacement method, and UV–Vis spectroscopy. The in vitro kinetics of drug release was also studied using First-order, Korsmeyer-Peppas, Hixon-Crowell, and Higuchi kinetic models. The SEM micrographs confirmed the formation of highly porous structures possessing well-defined, interconnected pore geometries. A significant reduction in the average pore sizes of the drug-loaded hydrogels was observed with the addition of ZNPs and CUR to the bare hydrogels. High value of drug loading efficiency (~ 72 %) and maximum drug release of about 50 % were obtained for the drug-loaded scaffolds. It was found that curcumin was transported via the non-Fickian diffusion mechanism. It was also shown that the kinetics of curcumin release was best described in order by Hixon-Crowell, Higuchi, and Korsmeyer-Peppas models, demonstrating that drug release was controlled by diffusion, degradation, and swelling of the drug carrier. However, lower degree of fitting was observed with First-order kinetic model.
Nima Hoseinizadeh, Farzaneh Kiarad, Zahra Kiani, Abolfazl Sadeghi, Azadeh Taherpour, Mehdi Shakibaie,
Volume 21, Issue 0 (3-2024)
Abstract
Glioblastoma multiforme is an aggressive brain tumor with limited therapeutic options. This study evaluated the multifunctional anticancer effects of curcumin-synthesized silver nanoparticles (curcumin-AgNPs) on the U-87 glioblastoma cell line. Curcumin-AgNPs were biosynthesized using curcumin as a reducing and stabilizing agent and characterized by ultraviolet–visible spectroscopy (UV–Vis), dynamic light scattering (DLS), and transmission electron microscopy (TEM). Cytotoxicity was assessed by MTT assay. The mRNA expression of apoptosis- and epithelial–mesenchymal transition (EMT)-related genes was quantified by real-time PCR. DLS and TEM analyses revealed curcumin-AgNPs with sizes of 56.27±4.59 nm and 22±3 nm, respectively. Curcumin-AgNPs reduced U-87 MG cell viability in a dose- and time-dependent manner. Analysis of apoptosis-related genes showed an increased BAX/BCL2L1 ratio. Additionally, FN1 and VIM were downregulated to 0.48- and 0.60-fold, respectively, indicating inhibitory effects on EMT and the metastatic potential of U-87 MG cells. These findings indicated that curcumin-AgNPs exhibit cytotoxic, pro-apoptotic, and EMT-modulating effects in U-87 MG cells, highlighting their potential as a multifunctional nanoplatform for glioblastoma research. Further studies are required to elucidate their underlying mechanisms.
Fatemeh Rafati, Narges Johari,
Volume 22, Issue 3 (9-2025)
Abstract
It must be recognized that the degree of this factor will influence how well wound-healing materials perform water absorption, protein interaction, and cellular adhesion. In the present study, we are concerned with studying the effects of polyethylene glycol (PEG) and curcumin (Cur) on the hydrophilicity of silk fibroin (SF)/linen (LN) composite films. The SF and LN composite films were blended at an equal mass ratio of 1:1, and PEG and Cur were also added to induce changes in surface properties. Fourier-transform infrared analyses showed that intermolecular interactions and hydrogen bonding were formed among the components in the blends. There was a very obvious hydrophobicity reduction by the addition of Cur and PEG/Cur, as exemplified by the static water contact angle measurements: simply addition of Cur to SF lowered the contact angle from approximately 100° to 72°, whereas a co-addition of PEG and Cur produced the greatest reduction (64°), equalling 70%. The synergistic effect in the surface wettability enhancement occurs because both additives introduce polar moieties onto the surface and partially disrupt the SF crystalline structure. Water uptake and cell viability tests further verified the hydrophilicity and biocompatibility of PEG/Cur-modified SF/LN films. This promotes the use of PEG/Cur-modified SF/LN blends as hydrophilic, bioactive materials suited for advanced wound dressing and tissue engineering scaffolds.
